Endocrine Abstracts

Macroprolactin is a bio-inactive molecule which cross-reacts in prolactin immune-assays. ‘Macroprolactinaemia’ describes hyperprolactinaemia which is entirely explained by the presence of macroprolactin. Failure to recognize macroprolactinaemia is associated with inappropriate investigation and unnecessary treatment. While screening for macroprolactinaemia is regularly undertaken in the UK and Ireland and to a lesser extent in continental European and Japan, this is ...

The 19th century saw the emergence of an extraordinarily gifted group of Dublin doctors who enjoy eponymous recognition. Immediately on graduating Robert Graves’ travelled for over 2 years to many of the foremost medical centres in Europe. On his return he introduced formal bedside teaching and daily lectures which has become the model for clinical training in these islands. Graves’ main other interest was the treatment of febrile illness recognizing the importance o...

The 19th century saw the emergence of an extraordinarily gifted group of Dublin doctors who enjoy eponymous recognition. Immediately on graduating Robert Graves’ travelled for over 2 years to many of the foremost medical centres in Europe. On his return he introduced formal bedside teaching and daily lectures which has become the model for clinical training in these islands. Graves’ main other interest was the treatment of febrile illness recognizing the importance o...

Raised body mass index (BMI) is seen in 95% of PCOS patients, which is characterised by hyperandrogenaemia, both clinically and biochemically. Weight loss, using calorie restricted diets, have previously been successful in improving androgen profiles and also restoring fertility in obese PCOS patients. A CB1 cannabinoid receptor antagonist, rimonabant is effective in achieving weight loss in subjects with a BMI >27 kg/m.This study aimed to...